Study shows heart failure treatment with dapagliflozin consistently benefited both men and women

Nov. 10, 2022
Brigham and Women's Hospital study.

When it comes to heart failure (HF), sex differences are known to impact everything from risk factors to clinical presentation to response to treatment, making sex a key factor to consider in studies of emerging pharmacotherapies.

Sodium-glucose cotransporter-2 (SGLT2) inhibitors, such as dapagliflozin, have become an important pharmacotherapy solution for patients with HF, yet more data are needed to assess their effect and safety between sexes.

Investigators from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, conducted a study to rectify this gap in knowledge, using a pre-specified patient-level pooled analysis of DAPA-HF (Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure) and DELIVER (Dapagliflozin Evaluation to Improve the Lives of Patients with Preserved Ejection Fraction Heart Failure).

Clinical outcomes for 11,007 randomized patients, 35-percent of whom were women, were compared by sex across the spectrum of left ventricular ejection fraction. In both DAPA-HF and DELIVER, men and women responded similarly and positively to dapagliflozin when it came to primary outcomes of worsening HF or cardiovascular death, and secondary outcomes of general health status.

Read more in Circulation.

Brigham and Women's Hospital release on Newswise