IU cancer center researchers identify biology behind aggressive breast cancers in Black women

Oct. 30, 2023
Study published recently in the journal Nature Communications.

Researchers at Indiana University Melvin and Bren Simon Comprehensive Cancer Center are unlocking the biology behind aggressive breast cancers in Black women.   

Led by Harikrishna Nakshatri, PhD, this study could lead to new targeted treatments to lessen the disparities in breast cancer among Black women. Nakshatri is the Marian J. Morrison professor of breast cancer research at IU School of Medicine and a researcher with the Vera Bradley Foundation Center for Breast Cancer Research at the IU Simon Comprehensive Cancer Center. 

The Nakshatri lab has been focused on understanding how genetic ancestry influences the biology of normal breast tissue and how it factors into the development of aggressive breast cancers. 

Nakshatri’s research previously found that normal breast tissue in women of African ancestry contains a cell type called PZP at a much higher number when compared to normal breast tissue of Caucasian women. PZP cells increase when Caucasian women develop breast cancer, while they are naturally higher in Black women. 

Now, Nakshatri and colleagues have discovered that PZP cells can influence how cancer cells behave and grow as they interact with another cell type—epithelial cells—where breast cancer generally originates. Additionally, they have found that PZP cells are one of the cells of origin for rare and aggressive metaplastic breast cancers (MBC), which account for less than 1 percent of all breast cancers. These findings were published recently in the journal Nature Communications. 

Researchers used tissue samples from the Susan G. Komen Tissue Bank at the IU Simon Comprehensive Cancer, the world’s only healthy breast tissue bank.  

“We found when these PZP cells are in association with the epithelial cells, the PZP cells start making a protein called interleukin-6 (IL-6). The epithelial cells start behaving differently, and a signal called STAT3 gets activated,” Nakshatri said. “That's how it will make tumors developing from the epithelial cells more aggressive.” 

Indiana University release on Newswise

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