An emulated target trial of more than 140,000 women in Denmark found that removing the ovaries at benign hysterectomy was associated with increased risk for cardiovascular disease in younger women and cancer in older women at low risk for ovarian cancer. These findings support current recommendations for preserving ovaries in premenopausal patients. The findings are published in Annals of Internal Medicine.
Removal of the ovaries decreases the risk for ovarian cancer and greatly benefits the survival of women at high risk for ovarian cancer. However, not enough is known about how removal of the ovaries affects other possible outcomes, such as heart attack, stroke, other types of cancer, and how long patients live.
Researchers from the Danish Cancer Society Research Center, Copenhagen, Denmark studied health records for 142,985 women who underwent a benign hysterectomy with or without bilateral salpingo-oophorectomy (removal of the ovaries and fallopian tubes) to compare long-term outcomes. The researchers found that women who had their ovaries removed had a lower risk of ovarian cancer, but other health outcomes varied by age/menopause status. Premenopausal women who had ovaries removed had a higher risk of hospitalization for cardiovascular disease. Perimenopausal, early postmenopausal, and late postmenopausal women who had ovaries removed had a higher risk for cancer. The authors noted that women who had their ovaries removed at perimenopausal ages had more deaths when measured at 10 and 20 years after surgery, but women aged 65 years or older had fewer deaths when measured at 20 years after surgery. According to the authors, these results suggest a cautious approach to removing ovaries in women at low risk for ovarian cancer.
