Decreasing the rate of missed lesions could translate into fewer cases of colon cancer

Sept. 23, 2021

A multicenter team of researcher-clinicians led by gastroenterologists at Beth Israel Deaconess Medical Center (BIDMC) assessed whether artificial intelligence-based computer aided adenoma detection can improve colonoscopy quality by reducing the miss rate.

The researchers reported a relative reduction of the miss rate by nearly a third when computer-aided detection was used in conjunction with standard-of-care colonoscopy. The study is the first randomized trial examining the role of a deep-learning based computer-aided detection system during colonoscopy in the United States, according to BIDMC.

Colorectal cancer is the third most diagnosed cancer and the second leading cause of cancer deaths in the United States. Regular screening for pre-cancerous lesions called adenomas has been shown to reduce the risk of death from colon cancer by more than 60%. However, adenoma detection rates and, conversely, adenoma miss rates vary greatly across physicians, with miss rates ranging from 6% to 41%.

“Our study demonstrates that computer-aided polyp detection has the potential to decrease variability in colonoscopy quality among providers by reducing the miss rate even for experienced physicians,” said senior author Tyler M. Berzin, MD, Director of the Advanced Endoscopy Fellowship at BIDMC.

The study published in Clinical Gastroenterology and Hepatology.

For the prospective, multicenter trial, researchers enrolled 223 patients presenting for colorectal cancer screening or surveillance at four academic medical centers in the U.S. from 2019 through 2020. All patients underwent both the standard high-definition, white light colonoscopy and a computer-aided detection assisted colonoscopy. Half were randomized to undergo the standard colonoscopy first, followed immediately by the other procedure in tandem fashion by the same endoscopist. The other enrollees were randomized to receive the procedures in reverse order.

The team found that for the group that underwent computer-aided colonoscopy first, the adenoma miss rate was just above 20%, significantly lower than the 34% miss rate among those who received standard high-definition white light colonoscopy first.

“This trial has implications beyond colorectal screenings, as we believe it to be one of the first U.S. prospective randomized control trials evaluating an artificial intelligence technology in any field of medicine,” said Jeremy R. Glissen Brown, MD, Fellow in the Division of Gastroenterology & Hepatology at BIDMC. “While deep learning for the purposes of artificial intelligence has been area of intense commercial and research focus for the past five years, it is crucial that we collect high-quality, rigorous data in the form of randomized clinical trials in order for us to incorporate AI safely and effectively in medical practice.”

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