Thermo Fisher Scientific, Inc., has introduced its Mass Spectrometric Immunoassay (MSIA) pipette tips, a collection of immunoaffinity sample preparation products. Company representatives assert that this new technology makes enriching target proteins simpler, resulting in accelerated discoveries for mass spectrometric analysis. Says Clive Winger, business director, affinity & automation consumables, Thermo Fisher Scientific: “Our new MSIA pipette tips provide scientists with an easier immunoaffinity approach that yields better and more reproducible quantification results.”
MSIA tips feature a 300 µl pipette tip embedded with a proprietary, highly porous immunoaffinity column that provides increased sensitivity with improved reproducibility and sample throughput. Thermo Fisher Scientific spokespersons say that its benefits include enhanced antibody/antigen-binding kinetics that allow enrichment down to very low levels for downstream mass spectrometric protein/peptide quantification; improved signal-to-noise ratios due to increased specificity and target recovery as compared to conventional bead-based methods; fast and flexible sample throughput with manual multichannel or fully automated 96-well processing in less than 30 minutes; and customizable assay that meets different biomarker research needs.
The new MSIA D.A.R.T.’s (Disposable Automation Research Tips) are compatible with the Thermo Scientific Versette Automated Liquid Handler, providing immuno-enrichment processing in 96-well format. In addition, the new Thermo Scientific Finnpipette Novus i 8- and 12-channel Electronic Pipettes (for immuno-precipitation) and Adjustable Pipette Stand are designed to work with MSIA protocols where high sample throughput is not required. Learn more about MSIA pipette tips, with a link to a technology video.