ENZAMET shows promise as prostate cancer treatment

March 31, 2023
New study.

A new drug combination for men with advanced prostate cancer has shown sustained increase in survival rates.

The results from the clinical trial of ENZAMET, co-chaired by Professor Christopher Sweeney, Director of the South Australian immunoGENomics Cancer Institute (SAiGENCI) that operates within the University of Adelaide, have been published in The Lancet Oncology

For people with metastatic hormone-sensitive prostate cancer, the addition of an androgen receptor blocker with enzalutamide to standard therapy – suppression of testosterone, with or without chemotherapy - led to a 67 percent survival rate after five years. 

This compares to 57 percent of people who were alive after five years after receiving the standard best practice treatment. 

ENZAMET (ANZUP 1304) is a global collaborative investigator-initiated trial led by the Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP). 

The side effects of the addition of enzalutamide to standard of care were overall similar to what has been experienced with enzalutamide in previous clinical trials. 

The University of Adelaide release