New clues to how the tumor microenvironment impacts pancreatic cancer

Aug. 23, 2022
GOT2 causes metabolic changes that pancreas tumors overcome.

Within a pancreatic cancer tumor, different cell types interact to facilitate the tumor’s growth. Researchers see disrupting this metabolic crosstalk as a compelling target for treatment.

In a new study published in eLife, researchers from the University of Michigan Rogel Cancer Center looked at the mitochondrial metabolism, which is key driver of pancreatic cancer.

By looking at cell lines, they found loss of the mitochondrion GOT2 causes metabolic changes that impair cellular growth. But in engineered mice, loss of GOT2 had no effect on tumor growth or initiation.

Cancer cells use a complex cell-intrinsic rewiring and crosstalk with the tumor microenvironment in vivo. These data emphasize an under-appreciated role for GOT2 in pancreatic tumor redox homeostasis and illustrate the way cancer cells use biochemical pathways and metabolic plasticity to grow in vivo.

U of M Health release