Large study shows that Covid-19 vaccination does not affect fertility or early pregnancy

Feb. 2, 2022

Vaccination against COVID-19 did not affect fertility outcomes in patients undergoing in-vitro fertilization (IVF), a new study has found as described in a news release from Mount Sinai.

The findings, which were published in Obstetrics & Gynecology (the Green Journal), add to the growing body of evidence providing reassurance that COVID-19 vaccination does not affect fertility.

Investigators at the Icahn School of Medicine at Mount Sinai and Reproductive Medicine Associates of New York (RMA of New York) compared rates of fertilization, pregnancy, and early miscarriage in IVF patients who had received two doses of vaccines manufactured by Pfizer or Moderna with the same outcomes in nonvaccinated patients.

“This is one of the largest studies to review fertility and IVF cycle outcomes in patients who received COVID-19 vaccinations. The study found no significant differences in response to ovarian stimulation, egg quality, embryo development, or pregnancy outcomes between the vaccinated compared to unvaccinated patients.” said Devora A. Aharon, MD, Fellow in Reproductive Endocrinology and Infertility at Icahn Mount Sinai and RMA of New York. “Our findings that vaccination had no impact on these outcomes should be reassuring to those who are trying to conceive or are in early pregnancy.”

The study involved patients whose eggs were collected from the ovaries and fertilized by sperm in a laboratory, creating embryos that were frozen and later thawed and transferred to the womb, and patients who underwent medical treatment to stimulate the development of eggs. The two groups of patients who underwent frozen-thawed embryo transfer — 214 vaccinated and 733 unvaccinated — had similar rates of pregnancy and early pregnancy loss. The two groups of patients who underwent ovarian stimulation — 222 vaccinated and 983 unvaccinated — had similar rates of eggs retrieved, fertilization, and embryos with normal numbers of chromosomes, among several other measures.

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