Update of lung injuries associated with use of e-cigarette or vaping products

Oct. 21, 2019

As of October 15, 2019, 1,479 confirmed and probable lung injury cases associated with use of e-cigarette, or vaping products were reported by 49 states (all except Alaska), the District of Columbia, and the U.S. Virgin Islands.

Among 849 patients with information on substances used in e-cigarette or vaping products in the three months prior to symptom onset:

·        78% reported using THC-containing products, with or without nicotine-containing products;

·         31% reported exclusive use of THC-containing products;

·         58% reported using nicotine-containing products, with or without THC-containing products; and

·         10% reported exclusive use of nicotine-containing products.

The median age of patients who have died is 44 years, ranging from 17 to 75 years old. Among 1,358 patients with data on age and sex:

·         70% of patients are male; and

·         79% of patients are under 35 years old.

·         The median age of patients is 23 years, and ages range from 13 to 75 years old.

Thirty-three deaths have been confirmed in 24 states: Alabama, California, Connecticut, Delaware, Florida, Georgia, Illinois, Indiana, Kansas, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, New Jersey, New York, Oregon, Pennsylvania, Tennessee, Texas, Utah and Virginia.

In addition, CDC is now:

·         Performing additional laboratory testing.

·         Validating targeted methods to test chemicals in bronchoalveolar lavage (BAL) fluid, blood, or urine and has received initial samples for testing.

·         Testing pathologic specimens, including lung biopsy or autopsy specimens, associated with patients.

·         Validating methods for aerosol emission testing of case-associated product samples from e-cigarette, or vaping, products and e-liquids. Initial data from product sample testing has guided the need for these additional assays.

Results may provide insight into the nature of the chemical exposure(s) contributing to this outbreak.

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