Thermo Fisher Scientific recently unveiled the Thermo Scientific Orbitrap Isora Mass Spectrometer and Orbitrap Isora Pro Mass Spectrometer, the company’s first Orbitrap instruments with a dedicated isotope ratio analysis mode.

Together with the Thermo Scientific Vanquish Duo UHPLC System and new Isotope Discoverer Software, the instruments form an integrated workflow designed to make molecular-level isotope ratio analysis accessible to more laboratories and researchers worldwide.

Unlike traditional isotope ratio techniques that require samples to be converted to a simple gas, the Orbitrap Isora workflow measures isotope ratios directly at the molecular level, providing a more detailed picture of a sample’s origin and history. At the same time, the workflow simplifies an analysis that previously required multiple script-based tools and complex manual data processing. The Orbitrap Isora workflow brings these steps together, delivering results in hours instead of days and making isotope analysis more practical for a broader range of laboratories. The workflow includes:

• The Orbitrap Isora MS and Orbitrap Isora Pro MS, which combine electrospray ionization (ESI) with high-resolution accurate-mass (HRAM) detection to measure isotopologues and isotope ratios directly from intact molecular ions. The instruments capture multiple isotopes in a single run and offer researchers different levels of analytical capability, with up to 240K maximum resolution (at m/z 200) on Orbitrap Isora MS and up to 480K maximum resolution (at m/z 200) on Orbitrap Isora Pro MS.
• The Vanquish Duo UHPLC System, which automates the introduction of samples and reference materials, using known standards to help ensure accurate, reliable isotope ratio measurements.
• New Isotope Discoverer Software, which turns the resulting isotope data into usable results by extracting isotope ratios, filtering data and applying corrections, all in one environment.

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