Thermo Fisher Scientific introduced the Gibco CTS AAV-MAX Helper-Free AAV Production System, a new all-in-one system designed to help meet clinical and commercial demands for cost-effective and scalable development of adeno-associated virus (AAV)-based gene therapies.
AAV is used in 82% of viral vector-based gene therapies in the pipeline, and scaled production is critical to accelerate the transition from research to commercialization to bring gene therapies to market faster and at lower costs. By delivering high titer AAV production, the system can save manufacturers up to 50% on production costs compared to alternative polyethyleneimine (PEI)-based suspension systems and help reduce plasmid DNA costs by 25%. It features a mammalian-based suspension system comprised of a clonal HEK293 cell line and animal origin-free reagents that support scalable AAV production from shake flask to bioreactor scale.
The CTS AAV-MAX System is designed to work within the AAV production workflow, from cell culture and transfection through AAV viral vector production. Researchers can transition from research on the Gibco AAV-MAX Helper Free AAV Production System to clinical scale using the CTS AAV-MAX System.
