Leica Biosystems launches ChromoPlex III detection system

July 23, 2025

Leica Biosystems unveiled ChromoPlex III Triple Detection RUO, a chromogenic multiplex immunohistochemistry detection system engineered to simplify assay setup and reduce variability. ChromoPlex III is built to fit seamlessly into Leica Biosystems’ end-to-end translational research ecosystem—stain on BOND RX, scan with Aperio, and analyze with HALO.

The launch comes as researchers seek more accessible and clinically relevant multiplex IHC tools to advance spatial biology and better characterize the tumor microenvironment. ChromoPlex III meets these needs by delivering consistent, reproducible chromogenic staining optimized for high-resolution digital imaging and computational pathology workflows.

ChromoPlex III’s plug-and-play format reduces manual steps and eliminates the need for antibody conjugation. Researchers simply select their antibodies, assign chromogen colors (brown, red, or green), load the kit onto the BOND RX or RXm stainer, and initiate their assay. With pre-optimized reagents and protocols, ChromoPlex III helps streamline detection workflows and minimizes setup variability.

ChromoPlex III is available now for research use only.

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