New data from TERAVOLT, a global consortium that tracks outcomes of people with thoracic cancers affected by COVID-19, offers clues as to why they experienced a high death rate of 33 percent when the coronavirus swept across Europe.
While the majority of those who died were hospitalized, only 9 percent were admitted to intensive care units, according to a study published in The Lancet Oncology. Most died from complications of COVID-19, not the progression of cancer.
“Just having a lung cancer diagnosis in and of itself shouldn’t exclude patients from care,” said Leora Horn, MD, MSc, Ingram Associate Professor of Cancer Research at Vanderbilt-Ingram Cancer Center, who is a senior author of the study and a TERAVOLT consortium steering committee member.
The study is based on the first 200 patients for which TERAVOLT received outcomes data. Of the 152 hospitalized patients, 134 (88 percent) met the criteria for ICU admission, but only 13 of those patients were admitted to an ICU. Only five were mechanically ventilated.
Most of the patients were hospitalized in Italy, France and Spain, which were “particularly hard hit” by the pandemic, the study noted. The study’s lead author, Marina Garassino, MD, of the National Cancer Institute of Milan, Italy, initiated the idea for the registry, which led to the TERAVOLT consortium (Thoracic cancERs InternAtional coVid 19 cOLlaboraTion).
Initial data indicated that patients on tyrosine kinase inhibitors appeared to be at decreased risk for hospital admission. This remained true when Horn presented updated data from the TERAVOLT registry last month at ASCO20 Virtual, the annual meeting of the American Society of Clinical Oncology. The data presented at the ASCO meeting were based on those first 200 patients in the study, plus an additional 200, including many from the United States.
That data revealed that patients treated with chemotherapy within three months of a COVID-19 diagnosis had a significantly increased risk of 64 percent of dying from the coronavirus. Patients treated with anticoagulants to prevent blood clots and corticosteroids to reduce inflammation also had a greater mortality risk. Patients treated with immunotherapies had no increased risk of mortality.
The TERAVOLT registry is an ongoing longitudinal study. Data collected from consortium participants across the globe are entered on a REDCap database hosted by Vanderbilt. The registry recently received $95,000 in funding support from the International Association for the Study of Lung Cancer on behalf of the Lung Ambition Alliance.
