Response-adapted ultra-low dose radiation achieves complete response in 90% of patients with orbital indolent B-cell lymphomas

Oct. 24, 2022
Results from MD Anderson-led Phase II trial presented at ASTRO 2022.

Using a novel response-adapted ultra-low dose radiation therapy strategy, researchers at The University of Texas MD Anderson Cancer Center observed a 90% complete response rate in patients with orbital indolent B-cell lymphoma. Results were presented today at the 2022 American Society for Radiation Oncology (ASTRO) Annual Meeting. 

This study, led by Chelsea C. Pinnix, M.D., Ph.D., associate professor of Radiation Oncology, prospectively examined the use of a response-adapted strategy in this setting, allowing patients who have a complete response to ultra-low radiation doses — 4 Gray (Gy) in two fractions — to forego the higher standard doses. The treatment was associated with limited side effects, suggesting the response-adapted approach could improve quality of life without limiting efficacy. 

Indolent B-cell lymphoma includes mucosa-associated lymphoid tissue (MALT) lymphoma, follicular lymphoma and unclassifiable B-cell lymphoma. Traditionally, patients have received higher doses of radiation, ranging from 24 - 30 Gy, which can result in significant acute and long-term toxicity to the orbital region, or the area surrounding the eyes and related organs. Due to concerns for toxicity, some physicians have opted to observe patients with recently diagnosed indolent B-cell lymphoma of the orbit instead of proceeding with immediate radiation therapy. 

In this Phase II trial, researchers aimed to achieve the same disease outcomes when using a response-adapted radiation therapy strategy as opposed to the standard upfront dose of 24 Gy. Patients were treated with 4 Gy in two fractions, and their responses were assessed at three-month intervals. Those who did not have a complete response to the initial ultra-low dose were offered treatment with 20 Gy to complete the standard dose of 24 Gy of radiation. Patients who experienced a complete response after the ultra-low dose were observed. 

The trial included 50 evaluable patients with stage I to stage IV orbital indolent B-cell lymphomas. The participants’ median age was 63 years, and 62% of participants were female. Most patients (62%) had stage I disease in one or both orbits. Sixty-four percent of participants had MALT lymphoma, 32% had follicular lymphoma and 12% had low-grade B-cell lymphoma. 

In a planned subset analysis of patients with newly diagnosed stage I MALT lymphoma, researchers observed a two-year local control rate of 91%. At two-year evaluation, 95% of these patients had not experienced a distant recurrence of disease. 

In the study, treatment-related side effects were limited. Three patients (6%) experienced grade 1 dry eye, and there were no grade 3 or higher toxicities. 

Researchers also conducted a retrospective study in a separate cohort of 55 patients who were treated with the same response-adapted ultra-low dose strategy. At a median follow-up of 37.3 months, 98% of patients had a complete response to the response-adapted radiation therapy strategy, with only two patients receiving an additional 20 Gy prior to experiencing a complete response. 

MD Anderson Cancer Center release