Ten metabolites associated with bile duct cancer identified

Nov. 17, 2021

Early-stage research has found 10 metabolites associated with bile duct cancer, and they might one day help create a urine test to identify the cancer.

The work is the result of a collaboration between Imperial College London and the Khon Kaen University in Thailand, who are working together to understand and reduce the disproportionately high rates of bile duct cancer in the Isaan peoples from the North-Eastern region of Thailand and Laos, according to a news release from Imperial College London. The research is published in the journal Scientific Reports.

In the United Kingdom, bile duct cancer is rare, with around two in every 100,000 people developing it, and the cause is unknown. However, in Thailand it affects more than 30 times that figure in the North-Eastern region alone (85 cases in every 100,000 people) with still higher figures across the river in Laos.

The study included 34 participants from Thailand and 32 participants from the U.K., including 14 participants with bile duct cancer in the Thai group and 10 in the UK group. The researchers note that the rarity of the cancer meant a bigger study wasn’t possible.

The participants provided urine samples which were assessed using liquid chromatography mass spectroscopy - a technique that separates and detects molecular components in a sample. This allowed the researchers to identify the metabolites in the participants’ urine.

While there were differences in the metabolites of the Thai and U.K. participants due to diet and weight, the researchers found 10 metabolites that appear to be related to the development of the types of cancers seen in both groups.

This may indicate that the different forms of bile duct cancer act in the same way in the body, the scientists say. This could mean that any test developed using these metabolites could be used universally, if proven successful.

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