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    APOE in Alzheimer's Disease: Genetic Variants, Mechanisms, and Therapeutic Implications

    May 2, 2025
    With the number of individuals with Alzheimer's disease (AD) and other dementias expected to triple over the next few decades, there is a push to unravel the brain changes involved with the disease. The genetics of AD is complex, but one gene, Apolipoprotein E (APOE) ε4, is known to be the strongest genetic risk factor for AD.

    Carriers of the APOE ε4 allele face higher risk for developing AD due to amyloid buildup, neuroinflammation, and tau pathology all while facing higher risk of treatment complications. Knowing who carries the APOE e4 allele and who develops AD—and how they can be treated—is an active area of investigation.

     

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