Molecular Devices, LLC. unveiled a major upgrade to its CellXpress.ai Automated Cell Culture System. With the integration of rocking incubation, the system now supports the development and long-term maintenance of brain organoids, dramatically reducing manual workload and enabling faster progress in neurodegenerative disease research.
Brain organoids—miniature 3D models of the human brain—are powerful tools for studying complex neurological conditions. But cultivating them is notoriously labor-intensive, often requiring over 100 days of daily feeding and monitoring due to their high metabolic demands and sensitivity to nutrient distribution. These demanding workflows can now be automated with a new rocking incubator ensuring consistent nutrient flow. By combining automation with AI-powered decision making, scientists can now ensure consistent, healthy organoid development over extended timescales without constant human oversight.
Manually maintaining just 10 brain organoid plates requires nearly 27 hours of hands-on time each week. Now, by automating the process, that same manual work is reduced to just a few hours.
Beyond time savings, the CellXpress.ai system brings scientific precision to brain organoid development. It automates feeding and imaging on a fixed schedule—including weekends—ensuring consistent treatment across samples and minimizing variability. The system also reduces cross-contamination risks, maintains optimal media conditions at 37°C, and captures full-well imaging with advanced feature analysis. Researchers can now track the entire cell journey over time, unlocking deeper insights while preserving culture integrity.
Learn more about the latest updates to the CellXpress.ai cell culture system here.
