Wellcome Sanger Institute implements Sapio LIMS for lab transformation program

The Wellcome Sanger Institute has selected Sapio Sciences' Informatics Platform as its central LIMS, transitioning from legacy systems to support large-scale genomic research, workflow automation, and AI integration, streamlining lab operations and data management.
Dec. 10, 2025
4 min read

Sapio Sciences announced that the Wellcome Sanger Institute has selected the Sapio Informatics Platform as its central LIMS to underpin the Institute’s ambitious lab transformation program.

The Sanger Institute will move from a patchwork of legacy LIMS solutions to a foundation centered on Sapio LIMS to support large-scale genomic research, demand planning and lab operations.

The multi-year digital transformation project is led by the Sanger Institute's Core Operations team, which sits at the heart of the Institute. Core Operations provides a broad range of cellular and genomic workflows that underpin the Institute’s end-to-end research and data-generation processes.

One of the initial goals of the transformation is to give Core Operations and scientific teams a clearer view of work coming into the lab, how that work moves through complex pipelines, resources that are required at each step, and provide access to key scientific data generated throughout the processing pipelines to scientists. The transformation will also focus on the workflows, data, and instruments used across the Cellular Platforms and Genomic Platforms teams and eventually extend across all research teams.

The transformation focuses on several key areas

  • Central LIMS foundation across the Sanger Institute: Sapio LIMS will become the dominant LIMS platform in Core Operations, underpinning all large-scale workflows across a wide range of technologies.
  • Full visibility of sample progress across complex workflows, providing users with real-time direct access to key scientific & QC data throughout
  • Advanced workflow automation and equipment integration: Sapio LIMS will support configurable workflows that span experiment preparation, lab execution and primary analysis, while integrating with a broad range of instruments. This includes the ability to connect to new, cutting-edge equipment that the Sanger Institute is often among the first to bring into routine use.
  • AI-ready lab infrastructure: The Sapio Informatics Platform will give the Sanger Institute a foundation for AI native capabilities such as guided workflows and smarter access to lab data, introduced in line with the Institute's principles so that scientists stay in control of decisions.
  • Consistent sample and data handling: The project will promote more consistent sample lifecycle management, clearer tracking of samples as they move through cellular and sequencing operations, and better linkage between samples, process steps and associated documentation.
  • Simplified LIMS landscape: As workflows move into Sapio LIMS, the Sanger Institute plans over time to retire some of their overlapping LIMS and point solutions and reduce complexity for users and support teams to encourage reuse and extension of existing capabilities instead of adding new point solutions.
  • Significantly accelerate the deployment of new technologies and workflows as core offerings to keep the Sanger Institute at the forefront of Genomic Research.
  • Stronger demand and resource planning: the Sanger Institute will build a better picture of demand across labs so Core Operations can plan work, schedule runs and coordinate equipment, people and materials across complex multi-step workflows.

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