What are the biggest MASLD death risk factors?

Sept. 19, 2025

A recent Keck Medicine of USC study identified the highest death risk factors for those with metabolic dysfunction-associated steatotic liver disease (MASLD). The findings are reported in a press release.

MASLD is classified as “the most common chronic liver disease in the world,” according to Keck Medicine. Of the MASLD-associated conditions, the researchers discovered which put patients at the most risk of death:

  • High blood pressure by 40%
  • Pre-diabetes or Type 2 diabetes by 25%
  • Low HDL by 15%

Patient demographics did not have any impact on risk factors, but obesity did raise a patient’s risk of dying from MASLD. Additionally, “the risk of death in MASLD patients increased by 15% for each additional cardiometabolic risk factor present.”

About the Author

Erin Brady

Managing Editor

Erin Brady is Managing Editor of Medical Laboratory Observer.

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