PSMA-PET may uncover more than traditional prostate cancer imaging

Feb. 5, 2025

UCLA research found evidence that imaging may not be showing how serious patients’ prostate cancer is.

According to a release, “nearly half of high-risk prostate cancer patients previously classified as nonmetastatic by conventional imaging actually have metastatic disease when evaluated with advanced prostate-specific membrane antigen–positron emission tomography (PSMA-PET) imaging, suggesting that traditional imaging may underestimate how far the cancer has spread in many cases.”

The researchers used PSMA-PET vs. traditional imaging for this study. They “conducted a post hoc, retrospective cross-sectional study using data from 182 patients with high-risk recurrent prostate cancers who were thought to have disease limited to the prostate and were eligible for the EMBARK trial.”

PSMA-PET revealed cancer metastases in 46% of people traditional imaging showed the cancer had not spread. PSMA-PET also found lesions traditional imaging had not.

The study was published in JAMA Network Open.

UCLA release

About the Author

Erin Brady

Managing Editor

Erin Brady is Managing Editor of Medical Laboratory Observer.

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