The Thermo Scientific E-CFEG, a low-energy-spread cold field emission source launched as a value-added component for the company’s highest-powered 300kV cryo-transmission electron microscope (cryo-TEM), is now also an option for the 200kV Thermo Scientific Glacios 2 Cryo-TEM.
This expanded offering is designed to help propel accessibility to cryo-electron microscopy (cryo-EM) techniques that boost resolution while maintaining ease-of-use and productivity capabilities. With a narrow energy spread to support high contrast images, the addition of the E-CFEG to the Glacios 2 Cryo-TEM enables near-atomic structural determination of complex proteins and macromolecules, and therefore, accelerated cryo-EM research and drug discovery processes using a lower accelerating voltage.
New data from Thermo Fisher Scientific using this combination demonstrates its ability to generate a 1.5 Å resolution structure of Apoferritin.
In a package that reduces workflow complexity for users of various experience levels for single particle analysis, cryo-electron tomography and Micro-ED workflows, the platform add-on also includes AI-enabled algorithms for data collection and automated microscope alignments for increased ease of use to enable users to produce consistently excellent data.
